AI Optimized My Supplement Stack

I fed my entire supplement stack to various AI models and asked them to come up with an optimal dosing and timing schedule for taking them.

"Optimal" means choosing the right overall dose, grouping nutrients based on synergies, while keeping those that interfere with each other apart, taking the right amount for my personal goals, as well as accounting for whether they are better taken with or without food.

All of the models struggled with the task (though it is an admittedly long list of supplements and a fairly complex request) and it took me three days to understand, modify, and verify the resulting plan as I had to improve how I was making my request and resolve some apparent errors and contradictions.

But in the end? My supplement game feels 10x more dialed in now than it was before. Some high-level notes:

— The vast majority of supplements should be spread out throughout the day and not taken in one large dose. This is because most of them have a very short half-life of a few hours or less. And the larger the dose, the steeper the curve at which the body eliminates them.

So now, if a dose requires 2 or 3 capsules, I take them separately, hours apart. In some cases, I even break open individual capsules and spread that throughout the day.

It sounds tedious but it's the difference between wasting your money and possibly overtaxing your body, or getting 3x the benefit from what you're taking.

— Many things should not be taken together (e.g. - various minerals, antioxidants, amino acids, etc.) because of chemical reactions or because they compete for transporters that can become quickly saturated.

— Many substances work far better when taken on an empty stomach. So now I use the window after waking up and an hour before breakfast as a valuable opportunity to get maximum benefit from certain supplements. Who knows whether I was even getting any benefit before.

It's only been a few days, and it could all be in my head, but I already feel better — like maybe my supplements are actually doing something. And now the way I was taking supplements before seems so primitive.

Supplements can be potent molecules, many of which have never existed in these concentrations before, and I think it's worth getting smart about them. I didn't expect it to take 3 almost straight days to accomplish the task when I embarked on it, but I learned way more and made way more changes than I could have imagined. And without AI, this would have taken me weeks.